Debbie Guerrero-Given

  • Email:

    debbie.guerrero-given@mpfi.org

Recent Papers

Presynaptic α2δs specify synaptic gain, not synaptogenesis, in the mammalian brain.

Milanick, W., Li, J., Thomas, C. I., Al-Yaari, M., Guerrero-Given, D., Kamasawa, N., & Young, S. M. (2025). Presynaptic α2δs specify synaptic gain, not synaptogenesis, in the mammalian brain. Neuron, 113(12), 1886-1897.e9.
 

Disrupting the transmembrane domain interface between PMP22 and MPZ causes peripheral neuropathy

Pashkova, N., Peterson, T. A., Ptak, C. P., Winistorfer, S. C., Guerrero-Given, D., Kamasawa, N., Ahern, C. A., Shy, M. E., & Piper, R. C. (2024). Disrupting the transmembrane domain interface between PMP22 and MPZ causes peripheral neuropathy. iScience, 110989.  

Presynaptic Rac1 controls synaptic strength through the regulation of synaptic vesicle priming.

Keine, C., Al-Yaari, M., Radulovic, T., Thomas, C. I., Valino Ramos, P., Guerrero-Given, D., Ranjan, M., Taschenberger, H., Kamasawa, N., & Young, S. M., Jr. (2022). Presynaptic Rac1 controls synaptic strength through the regulation of synaptic vesicle priming. ELife, 11, e81505.
 

Post-developmental plasticity of the primary rod pathway allows restoration of visually guided behaviors.

Cao, Y., Fajardo, D., Guerrero-Given, D., Samuel, M. A., Ohtsuka, T., Boye, S. E., Kamasawa, N., & Martemyanov, K. A. (2022). Post-developmental plasticity of the primary rod pathway allows restoration of visually guided behaviors. Current Biology, 0(0).
 

Gold In-and-Out: A Toolkit for Analyzing Subcellular Distribution of Immunogold-Labeled Membrane Proteins in Freeze-Fracture Replica Images.

Guerrero-Given, D., Goldin, S. L., Thomas, C. I., Anthony, S. A., Jerez, D., & Kamasawa, N. (2022). Gold In-and-Out: A Toolkit for Analyzing Subcellular Distribution of Immunogold-Labeled Membrane Proteins in Freeze-Fracture Replica Images. Frontiers in Neuroanatomy, 16. 

Adhesion GPCR Latrophilin 3 regulates synaptic function of cone photoreceptors in a trans-synaptic manner.

Wang, Y., Cao, Y., Hays, C.L., Laboute, T., Ray, T.A., Guerrero-Given, D., Ahuja, A.S., Patil, D., Rivero, O., Kamasawa, N., et al. (2021). Adhesion GPCR Latrophilin 3 regulates synaptic function of cone photoreceptors in a trans-synaptic manner. PNAS 118, (45) e2106694118. 

IgSF11 homophilic adhesion proteins promote layer-specific synaptic assembly of the cortical interneuron subtype

Hayano, Y. Ishino, J. Hyun, C. G. Orozco, A. Steinecke, E. Potts, Y. Oisi, C. I. Thomas, D. Guerrero-Given, E. Kim, H. Kwon, N. Kamasawa, and H. Taniguchi (2021) IgSF11 homophilic adhesion proteins promote layer-specific synaptic assembly of the cortical interneuron subtype. Science Advances 7, 29, eabf1600. 

A deep learning approach to identifying immunogold particles in electron microscopy images

Jerez, D., Stuart, E., Schmitt, K., Guerrero-Given, D., Christie, J. M., Hahn, W. E., Kamasawa, N., & Smirnov, M. S. (2021). A deep learning approach to identifying immunogold particles in electron microscopy images. Scientific Reports, 11(1), Article 1.
 

Targeting Functionally Characterized Synaptic Architecture Using Inherent Fiducials and 3D Correlative Microscopy.

Thomas, C.I., Ryan, M.A., Scholl, B., Guerrero-Given, D., Fitzpatrick, D., and Kamasawa, N. (2020). Targeting Functionally Characterized Synaptic Architecture Using Inherent Fiducials and 3D Correlative Microscopy. Microscopy and Microanalysis 1–14. 

ADAP1/Centaurin-α1 negatively regulates dendritic spine function and memory formation in the hippocampus.

Szatmari, E., Moran, C., Cohen, S., Jacob, A., Parra-Bueno, P., Kamasawa, N., Guerrero-Given, D., Klein, M., Stackman, R., and Yasuda, R. (2020). ADAP1/Centaurin-α1 negatively regulates dendritic spine function and memory formation in the hippocampus. ENeuro ENEURO.0111-20. 

Correlative Ultrastructural Analysis of Functionally Modulated Synapses Using Automated Tape-Collecting Ultramicrotome and SEM Array Tomography

Sun Y., Thomas C., Mikuni T., Guerrero-Given D., Yasuda R., Kamasawa N. (2020) Correlative Ultrastructural Analysis of Functionally Modulated Synapses Using Automated Tape-Collecting Ultramicrotome and SEM Array Tomography. In: Wacker I., Hummel E., Burgold S., Schröder R. (eds) Volume Microscopy. Neuromethods, vol 155. Humana, New York, NY.  

Presynaptic development is controlled by the core active zone proteins CAST/ELKS.

Radulovic T, Dong W, Goral RO, Thomas CI, Veeraraghavan P, Montesinos MS, Guerrero-Given D, Goff K, Lübbert M, Kamasawa N, Ohtsuka T, Young SM Jr. (2020) Presynaptic development is controlled by the core active zone proteins CAST/ELKS. J Physiol. 598(12):2431-2452.  

Presynaptic mitochondria volume and abundance increase during development of a high-fidelity synapse

Thomas, C.I., Keine, C., Okayama, S., Satterfield, R., Musgrove, M., Guerrero-Given, D., Kamasawa N, and Young, S.M. (2019). Presynaptic mitochondria volume and abundance increase during development of a high-fidelity synapse. J. Neurosc. 39 (41) 7994-8012. 

Caᵥ2.1 α₁ Subunit Expression Regulates Presynaptic Caᵥ2.1 Abundance and Synaptic Strength at a Central Synapse

Lübbert, M., Goral, R.O., Keine, C., Thomas, C., Guerrero-Given, D., Putzke, T., Satterfield, R., Kamasawa, N., and Young, S.M. (2019). CaV2.1 α1 Subunit Expression Regulates Presynaptic CaV2.1 Abundance and Synaptic Strength at a Central Synapse. Neuron 101, 260-273.e6. 

CAST/ELKS Proteins Control Voltage-Gated Ca⁺² Channel Density and Synaptic Release Probability at a Mammalian Central Synapse.

Dong, W., Radulovic, T., Goral, R.O., Thomas, C., Suarez Montesinos, M., Guerrero-Given, D., Hagiwara, A., Putzke, T., Hida, Y., Abe, M., Sakimura K., Kamasawa N., Ohtsuka T., Young S.M. Jr. (2018). CAST/ELKS Proteins Control Voltage-Gated Ca2+ Channel Density and Synaptic Release Probability at a Mammalian Central Synapse. Cell Reports 24, 284-293.e6. 

Identification of a highly neurotoxic α-synuclein species inducing mitochondrial damage and mitophagy in Parkinson’s disease.

Grassi, D., Howard, S., Zhou, M., Diaz-Perez, N., Urban, N.T., Guerrero-Given, D., Kamasawa, N., Volpicelli-Daley, L.A., LoGrasso, P., and Lasmézas, C.I. (2018). Identification of a highly neurotoxic α-synuclein species inducing mitochondrial damage and mitophagy in Parkinson’s disease. PNAS, 115(11):E2634-E2643. 

The Auxiliary Calcium Channel Subunit α2δ4 Is Required for Axonal Elaboration, Synaptic Transmission, and Wiring of Rod Photoreceptors

Wang, Y., Fehlhaber, K.E., Sarria, I., Cao, Y., Ingram, N.T., Guerrero-Given, D., Throesch, B., Baldwin, K., Kamasawa, N., Ohtsuka, T., et al. (2017). The Auxiliary Calcium Channel Subunit α2δ4 Is Required for Axonal Elaboration, Synaptic Transmission, and Wiring of Rod Photoreceptors. Neuron 93, 1359–1374.e6. 

Primary utricle structure of six Halimeda species and potential relevance for ocean acidification tolerance.

Peach, K., Koch, M.S., Blackwelder, P.L., Guerrero-Given, D., and Kamasawa, N. (2017). Primary utricle structure of six Halimeda species and potential relevance for ocean acidification tolerance. Botanica Marina - DE GRUYTER. 

Biofilm-specific extracellular matrix proteins of nontypeable Haemophilus influenzae.

Wu, S., Baum, M.M., Kerwin, J., Guerrero, D., Webster, S., Schaudinn, C., VanderVelde, D., and Webster, P. (2014b). Biofilm-specific extracellular matrix proteins of nontypeable Haemophilus influenzae. Pathog Dis 72, 143–160. 

Beta- lactam antibiotics stimulate biofilm formation in non-typeable haemophilus influenzae by up-regulating carbohydrate metabolism.

Wu, S., Li, X., Gunawardana, M., Maguire, K., Guerrero-Given, D., Schaudinn, C., Wang, C., Baum, M.M., and Webster, P. (2014a). Beta- lactam antibiotics stimulate biofilm formation in non-typeable haemophilus influenzae by up-regulating carbohydrate metabolism. PLoS ONE 9, e99204. 

Death and transfiguration in static Staphylococcus epidermidis cultures.

Schaudinn, C., Stoodley, P., Hall-Stoodley, L., Gorur, A., Remis, J., Wu, S., Auer, M., Hertwig, S., Guerrero-Given, D., Hu, F.Z., et al. (2014). Death and transfiguration in static Staphylococcus epidermidis cultures. PLoS ONE 9, e100002. 

Stay in touch,

Sign up to our Newsletter